Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity

J Med Chem. 1996 Aug 16;39(17):3238-40. doi: 10.1021/jm9603328.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Humans
  • Kinetics
  • Lipopolysaccharides / pharmacology
  • Lymphocytes / drug effects
  • Lymphocytes / immunology*
  • Molecular Structure
  • Phthalimides / chemical synthesis
  • Phthalimides / pharmacology
  • Pyrimidinones / chemical synthesis
  • Pyrimidinones / pharmacology
  • Structure-Activity Relationship
  • Thalidomide / analogs & derivatives*
  • Thalidomide / chemical synthesis*
  • Thalidomide / pharmacology
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / biosynthesis*

Substances

  • Lipopolysaccharides
  • Phthalimides
  • Pyrimidinones
  • Tumor Necrosis Factor-alpha
  • Thalidomide